Great overview of the work @newlimit is doing to extend human longevity Worth subscribing to @corememory on YouTube as well

@levelsio I just noticed that Home Depot's market cap is greater than that of than any EU company. So you could say that a vendor of air conditioners is worth more than any company in Europe... 🙈

Interesting chart. Would love to see the equivalent for some European index. A version that went further back would also be neat.

Today, we’re announcing @TrustVanta's Series D and new valuation – $4.15 billion – led by @Wellington_Mgmt alongside @sequoia, @ycombinator, @CrowdStrike, @GoldmanSachs, @jpmorgan, @craft_ventures, and @Atlassian. Vanta’s mission is to help businesses earn and prove trust.

Stripe's usage-based billing platform has grown 145% YTD. There's lots of discussion about when the industry will shift from seat-based pricing to consumption models, but it's clear in our data that the transition is already happening. I'm curious what the second-order effects of this change will be.

We're very proud that 75,000 new businesses have started their journey with @stripe.

Pieter Levels (@levelsio) and I sat down over a pint to talk about how he’s making $3m a year as a one-person company, what Europe can do to spur economic growth, and his experience as a digital nomad in over 150 cities across 40 countries. Timestamps 00:00 Intro 00:37 Pieter’s resume 01:33 Trying to make money online as a 12 year old 02:43 Being one of the first YouTube creators 03:18 Who should indie hack 04:31 What Pieter hates about VC-backed businesses 07:51 Who is digital nomading for? 09:15 Learning from @patio11 10:17 125k tweets and the brand of @levelsio 10:59 Getting referrals from ChatGPT 11:43 What Pieter automates with AI 13:02 Investing and home country bias 15:05 Hacking thermostats 15:57 EU acceleration movement 18:34 Entrepreneurship in the EU 19:26 Pieter's reflections on Stripe’s API 21:21 Looking 5 years into the future

When I tell you I inhaled this book, I mean I read it in one sitting, then 7 times over again. I've recommended it 57 times, gifted 12 copies, and lovingly annotated it on 6 flights. Donald Braben's Scientific Freedom is an eulogy to scientific discovery, autopsied while it was still alive. He predicted the current landscape of research, 17 years before it happened. We went from 500 people who could conduct and execute on research to 50,000 locked in cages of incremental work. Young scientists don't even bother anymore (they just leave). We didn't get dumber. We built a system that punishes risk. I would argue that most Nobel-winning discoveries from the 20th century would be rejected today (too weird! Too slow! Too uncertain!) Since 2008: > Peer review times have tripled > Federal grant success rates fall below 20% > First-time PI age is approaching 50 > (new!) Research funding cuts up to 43% I've spent the last few weeks mapping what Braben saw coming and stress-testing his arguments in 2025, what he missed, new challenges, and what we can adapt from here. Deep dive follows below! Very few books make me go wow, let alone restructure my entire paradigm. @stripepress knew what they were doing bringing this back. Everyone even remotely adjacent to scientific research needs to read this.

It’s interesting to me that when we look for guidance on big topics like, ”What does it mean to be a good person?”, or “What makes for a meaningful, worthwhile life?”, many of the canonical texts we regularly refer to are very old. Nicomachean Ethics, Meditations and the Bible, for instance, were written ~2K years ago. What should we make of this? Should we ‘expect’ our answers to these questions to evolve? I wrote some thoughts (and questions) on moral imagination. Link in reply.

Big news: we’re kicking off the search for ARIA’s next CEO. This is a once-in-a-lifetime opportunity to lead one of the most ambitious orgs in science and tech. 1/8